Bioavailability of Micronutrients From Nutrient-Dense Whole Foods: Zooming in on Dairy, Vegetables, and Fruits

Yang et al. used the random forest algorithm and 995 molecules to develop the admetSAR method with an accuracy of 69.7% . On the basis of 995 data points, Kim et al. obtained 76% accuracy using the logistic classifier method . Plasma data are most widely used and accepted method for the assessment of bioavailability of the drug product. The basic assumption in this method is that drug products that are bioequivalent product super imposable plasma level time curve.

Pharma IQ Glossary: Bioavailability

In pharmacology, the bioavailability is the ratio of the amount of a compound in circulation after its extravenous application and its intravenous injection. In aquatic toxicology, environmental bioavailability is usually relevant. Factors affecting the bioavailability of a chemical depend on the route of uptake, and whether the chemical is in the bottom sediment, dissolved in water, or is a constituent of the organisms. In the case of water-soluble substances, the primary source of toxicant is water, and the bioavailability depends on complex formation, especially with humic substances.

References

Case Studies on applying In Vitro Bioaccessibility and Relative probio one Data to Human Health Risk Assessment at Superfund Remedial and Removal sites. Attachments C – H provide examples of sites that have used site-specific bioavailability data in the Human Health Risk Assessment. The Absorption Fraction Parameter represents lead bioavailability in the Integrated Exposure Uptake Biokinetic Model for Lead in Children and the Absorption Fraction for Soil and Dust represents lead bioavailability in the Adult Lead Methodology Model. The 90% confidence intervals for the ratios of both Cmax and AUC should be contained within the limits 0.80–1.25 . But research has linked piperine — the active compound in black pepper — to better absorption of curcumin in your body (specifically an increase of 2000% in the bioavailability of curcumin). Upgraid’s special TurmiPure Gold formulation claims to increase the bioavailability of curcuminoids by 24 times.